Available in : Powder

Citrulline (L-Citrulline Base) in Capsules

Regular price 19,95€ i.e. 0,22€ / capsule
Sale price / Kg 19,95€ Regular price / Kg 0,00€ i.e. 0,22€ / capsule
  • Without Malates, GMO without allergen
  • Promotes anabolism and muscle congestion
  • Booster of no and sexual booster
  • The doser is not included in the 500g of powder jar
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The short lifespan of Citrulline in the blood suggests that this amino acid is used to use at least 2 times a day (2 capsules in the morning + 2 capsules in the evening) in order to obtain a constant elevation in the blood And therefore increase the anabolic response to training or/and its sexual prowess.

if you are only looking for congestion, the nutrimuscle base-base can be used, if possible with L-arginine Base Nutrimuscle , an hour before sporting or sexual activity at the rate of 4 capsules at once.
If some people quickly respond to the vasodilator effects of Citrulline, this is not the case for everyone. It takes 3 weeks of daily use of the Nutrimuscle base to determine the individual efficiency of this amino acid, in particular as a sexual boost.

Citrulline and side effects
Studies do not report any effect Secondary following moderate doses of citrulline. In strong doses (more than 10 g), some digestive disorders are reported.

All studies


  • Effet de l'extrait combiné de pépins de raisin et de la supplémentation en L-citrulline sur les réponses hémodynamiques à l'exercice chez les jeunes hommes
  • Une étude randomisée, en simple aveugle et croisée pour évaluer l'efficacité d'un nouveau mélange de compléments alimentaires avec de la L-citrulline sur les biomarqueurs d'hydratation, de taille musculaire, d'affect, d'inflammation et d'endurance musculaire
  • Influence du sexe sur l’impact physique et métabolique d’une intervention de 12 semaines combinant une supplémentation en citrulline et un entraînement par intervalles à haute intensité (HIIT) chez des personnes âgées
  • La supplémentation combinée en citrulline et en glutathion améliore la fonction endothéliale et la réactivité de la pression artérielle chez les femmes ménopausées
  • La supplémentation en l-arginine régule le métabolisme des substrats énergétiques dans le muscle squelettique et le tissu adipeux de rats obèses induits par l'alimentation
  • Éditorial pour le numéro spécial "Benefits of Supplementation with L-arginine, Citrulline and Watermelon on Vascular and Metabolic Health"


    (1) Kaore SN. citrulline: pharmacological perspectives and its role as an emerging biomarker in future. Fundam Clin Pharmacol. 2013 Feb;27(1):35-50.
    (1) Kaore SN. citrulline: pharmacological perspectives and its role as an emerging biomarker in future. Fundam Clin Pharmacol. 2013 Feb;27(1):35-50.
    (2) Crenn P. citrulline et métabolisme protéique. Nutrition Clinique et Métabolisme, 2008 22(2) June, Pages 75-79.
    (3) Hoogenraad N. Inhibition of intestinal citrulline synthesis causes severe growth retardation in rats. Am J Physiol. 1985 Dec;249(6 Pt 1):G792-9.
    (4) Osowska S. citrulline modulates muscle protein metabolism in old malnourished rats. Am J Physiol Endocrinol Metab. 2006 Sep;291(3):E582-6.
    (5) Moinard C. La citrulline exerce un effet direct sur la synthèse protéique musculaire Nutrition Clinique et Métabolisme 2007 21(Supplement 2) : 31-32.
    (6) Jourdan M. citrulline stimulates muscle protein synthesis at the post-absorptive state in healthy subjects fed a low protein diet. Clinical Nutrition 2008; 3 Supplement 1: 11-2.
    (7) Jourdan M. citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet - A pilot study. Clin Nutr. 2014 May 4.
    (8) Moinard C. citrulline: a new player in the control of nitrogen homeostasi J Nutr. 2007 Jun;137(6 Suppl 2):1621S-1625S.s.
    (9) Cynober L. The 2009 ESPEN Sir David Cuthbertson. citrulline: a new major signaling molecule or just another player in the pharmaconutrition game? Clin Nutr. 2010 Oct;29(5):545-51.
    (10) Breuillard C. citrulline and nitrogen homeostasis: an overview. Amino Acids 2015 47(4) pp 685-691.
    (11) Cynober L. Leucine and citrulline: two major regulators of protein turnover. World Rev Nutr Diet. 2013;105:97-105.
    (12) Sureda A. Arginine and citrulline supplementation in sports and exercise: ergogenic nutrients? Med Sport Sci. 2012;59:18-28.
    (13) El-Hattab AW. citrulline and Arginine utility in treating nitric oxide deficiency in mitochondrial disorders. Mol Genet Metab. 2012 Nov;107(3):247-52.
    (14) van de Poll MC. Interorgan amino acid exchange in humans: consequences for Arginine and citrulline metabolism. Am J Clin Nutr. 2007 Jan;85(1):167-72.
    (15) Rougé C. Manipulation of citrulline availability in humans. Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G1061-7.
    (16) Bahri S. citrulline: from metabolism to therapeutic use. Nutrition. 2013 Mar;29(3):479-84.
    (17) Jobgen WS. Regulatory role for the Arginine-nitric oxide pathway in metabolism of energy substrates. J Nutr Biochem. 2006 Sep;17(9):571-88.
    (18) Figueroa A. Impact of l-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function in obese postmenopausal women with high blood pressure. Exp Gerontol. 2015 Mar;63:35-40.
    (19) Kuhn E. [The effect of work load on amino acid metabolism]. Vnitr Lek. 1994 Jul;40(7):411-5.
    (20) Brodan V. Changes of free amino acids in plasma of healthy subjects induced by physical exercise. Eur J Appl Physiol Occup Physiol. 1976 Mar 9;35(1):69-77.
    (21) Sureda A. Blood cell NO synthesis in response to exercise. Nitric Oxide. 2006 Aug;15(1):5-12.
    (22) Wijnands KAP. Arginine and citrulline and the Immune Response in Sepsis. Nutrients 2015, 7(3), 1426-1463.
    (23) Luiking YC. Reduced citrulline production in sepsis is related to diminished de novo Arginine and nitric oxide production. Am. J. Clin. Nutr. 2009, 89, 142–152.
    (24) Wijnands KA. citrulline a more suitable substrate than Arginine to restore no production and the microcirculation during endotoxemia. PLoS One 2012, 7, e37439.F37
    (25) Piton G. Plasma citrulline kinetics and prognostic value in critically ill patients. Intensive Care Med. 2010, 36, 702–706.
    (26) Cynober L. citrulline: Just a biomarker or a conditionally essential amino acid and a pharmaconutrient in critically ill patients? Crit. Care 2013, 17, 122.
    (27) Asgeirsson T. citrulline: a potential immunomodulator in sepsis. Surgery. 2011 Oct;150(4):744-51.
    (28) Cynober L. citrulline: just a biomarker or a conditionally essential amino acid and a pharmaconutrient in critically ill patients? Crit Care. 2013 Mar 11;17(2):122.
    (29) van Wijck K. L-citrulline improves splanchnic perfusion and reduces gut injury during exercise. Med Sci Sports Exerc. 2014 Nov;46(11):2039-46.
    (30) Balderas-Munoz K. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J. 2012;19(6):612-7.
    (31) Ochiai M. Short-term effects of L-citrulline supplementation on arterial stiffness in middle-aged men. Int J Cardiol. 2012 Mar 8;155(2):257-61.
    (32) Figueroa A. Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men. Am J Hypertens. 2010 Jan;23(1):12-6.
    (33) Sanchez-Gonzalez MA. The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise. Am J Hypertens. 2013 Apr;26(4):518-26.
    (34) Pernow J. Arginase as a potential target in the treatment of cardiovascular disease: reversal of Arginine steal? Cardiovasc Res. 2013 Jun 1;98(3):334-43.
    (35) Kim NN. Role of arginase in the male and female sexual arousal response. J Nutr. 2004 Oct;134(10 Suppl):2873S-2879S.
    (36) Lucas R. Arginase in the vascular endothelium: friend or foe? Front Immunol. 2014 Nov 17;5:589.
    (37) Cormio L. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22.


Take 4 capsules per day, either 1 hour before training, or distributed in the morning and evening meal.

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07:00

Breakfast

17:00

1 hour before training

20:00

At dinner

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Kéto Pesco-végétarien Sans biotiques Sans caséine Sans gluten Sans lactose Vegan Végétarien

The L-Citrulline is an unprotal semi-semi-semi-sisters acid. Citrulline is said to be non -protein, because, unlike other conventional amino acids, food does not bring citrulline.
There is only the watermelon that brings a little (about 1 g per kilo). Consequently, our entire Citrulline must be synthesized from the intestinal destruction of various other amino acids such as glutamine and arginine. In return, at the level of the kidneys, the Citrulline is massively converted into arginine.

focus image
  • Kéto Pesco-végétarien Sans biotiques Sans caséine Sans gluten

    The L-Citrulline is an unprotal semi-semi-semi-sisters acid. Citrulline is said to be non -protein, because, unlike other conventional amino acids, food does not bring citrulline.
    There is only the watermelon that brings a little (about 1 g per kilo). Consequently, our entire Citrulline must be synthesized from the intestinal destruction of various other amino acids such as glutamine and arginine. In return, at the level of the kidneys, the Citrulline is massively converted into arginine.

Good to know

La Citrulline est idéale à intégrer dans votre shaker avec de la Bêta-alanine et de l'Arginine pour confectionner votre préworkout. 

Composition

Everything about this product

Interaction with other Nutrimuscle products

  • There is a synergy between the Nutrimuscle Base Citrulline and L-arginine Base Nutrimuscle to increase the secretion of NO as much as possible. Arginase is an enzyme present in the digestive system, the liver as well as on the vascular walls. As her name suggests, she is responsible for destroying Arginine (34). It prevents the arrival of the arginine that we absorb (in the form of food or supplement) in the blood. It also blocks the transformation of arginine into no due to its vascular presence. Another consequence of this overproduction of arginase is a greater difficulty in obtaining an erection.

    on the other hand, a physical activity multiplies by six the activity of this destructive of Arginine (19). Paradoxically, arginine's taking increases the activity of arginase which can minimize the effectiveness of arginine supplementation. On the contrary, Citrulline reduces the activity of arginase (36). There is thus a synergy between these two amino acids to facilitate anabolism, congestion and erection.


    antagonisms between supplements
    No negative interaction known with other supplements.

  • No negative interaction known with other supplements

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  • It is rare to know the names of the suppliers of the raw materials of the supplements that we consume. However, it is essential in order to ensure the traceability of the product.

    The Base-Citrulline is a form of pure l-citrulline. At Nutrimuscle, we only use very high-end L-Citrulline whose quality is guaranteed by the Japanese leader in pharmaceutical biotechnology, Biokyowa Inc. Biokyowa included HACCP and ISO9001 is specialized in the production of pure amino acids For over 30 years. Indeed, what matters primarily to us is the quality of raw materials, your health and the results you will get using our nutritional supplements. This quality is essential for amino acids such as the Nutrimuscle Base Citrulline that you often consume (every day or even several times a day) and in large quantities.

Celline benefits

Who is the product for?

  • To sportsmen for its anabolic action on muscles;
    to sedentary for its multiple health benefits of the organism or as a sexual booster.

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