Citrulline (L-Citrulline Base) in Capsules

There is a synergy between the Nutrimuscle Base Citrulline and L-arginine Base Nutrimuscle to increase the secretion of NO as much as possible. Arginase is an enzyme present in the digestive system, the liver as well as on the vascular walls. As her name suggests, she is responsible for destroying Arginine (34). It prevents the arrival of the arginine that we absorb (in the form of food or supplement) in the blood. It also blocks the transformation of arginine into no due to its vascular presence. Another consequence of this overproduction of arginase is a greater difficulty in obtaining an erection.

on the other hand, a physical activity multiplies by six the activity of this destructive of Arginine (19). Paradoxically, arginine's taking increases the activity of arginase which can minimize the effectiveness of arginine supplementation. On the contrary, Citrulline reduces the activity of arginase (36). There is thus a synergy between these two amino acids to facilitate anabolism, congestion and erection.


antagonisms between supplements
No negative interaction known with other supplements.

No negative interaction known with other supplements

(1) Kaore sn. Citrulline: Pharmacological Perspectives and its Role as an Emerging Biomarker in Future. Fundam clin pharmacol. 2013 Feb; 27 (1): 35-50.
(1) Kaore sn. Citrulline: Pharmacological Perspectives and its Role as an Emerging Biomarker in Future. Fundam clin pharmacol. 2013 Feb; 27 (1): 35-50.
(2) Crenn P. Citrulline and protein metabolism. Clinical nutrition and metabolism, 2008 22 (2) June, pages 75-79.
(3) Hoogenraad N. Inhibition of intestinal Citrulline synthesis Causes Severe Growth Delaying in rats. Am J Physiol. 1985 DEC; 249 (6 pt 1): G792-9.
(4) Osowska S. Citrulline MUSCULATES MUSCLE PROTEIN METABOLISM in Old Malnoudé Rats. AM J Physiol Endocrinol metab. 2006 Sep; 291 (3): E582-6.
(5) Moinard C. Citrulline has a direct effect on Muscle Protein Synthesis Clinical Nutrition and Metabolism 2007 21 (Supplement 2): 31-32.
(6) Jourdan M. Citrullline Stimulates Muscle Protein Synthesis at the post-absorptive state in healthy subjects fed a low protein diet. Clinical Nutrition 2008; 3 Supplement 1: 11-2.
(7) Jourdan M. Citrulline Stimulates Muscle Protein Synthesis in the post-Absorptive State in Healthy People Fed a Low-Protein Diet-A Pilot Study. Clin Nutr. 2014 May 4.
(8) Moinard C. Citrulline: A New Player in the Control of Nitrogen Homeostasi J Nutr. 2007 Jun; 137 (6 Suppl 2): ??1621S-1625S.S.
(9) Cynober L. The 2009 ESPEN SIR David CUTHBERTSON. Citrulline: A New Major Signaling Molecule Or Just Another Player in the Pharmaconutrition Game? Clin Nutr. 2010 Oct; 29 (5): 545-51.
(10) Breuillard C. Citrulline and Nitrogen Homeostasis: An Overview. AMINO ACIDS 2015 47 (4) pp 685-691.
(11) Cynober L. Leucine and Citrulline: Two Major Regulators of Protein Turnover. World Rev Nutr Diet. 2013; 105: 97-105.
(12) SURÉDA A. Arginine and Citrulline Supplementation In Sports and Exercise: Ergogenic Nutrients? Med Sport SCI. 2012; 59: 18-28.
(13) El-Hattab aw. Citrullline and Arginine Utility in Treating Nitric Oxide Deficiency in Mitochondrial Disorders. Mol Genet Metab. 2012 Nov; 107 (3): 247-52.
(14) Van de Poll Mc. Interorgan Amino Acid Exchange in Humans: Consequences for Arginine and Citrulline Metabolism. AM J Clin Nutr. 2007 Jan; 85 (1): 167-72.
(15) Rougé C. Manipulation of Citrulline Availability in Humans. AM J Physiol Gastrointest Liver Physiol. 2007 Nov; 293 (5): G1061-7.
(16) Bahri S. Citrulline: From Metabolism to Therapeutic Use. Nutrition. 2013 Mar; 29 (3): 479-84.
(17) Jobgen WS. Regulatory Role for the Arginine-Nitric Oxide Pathway in Metabolism of Energy Substrates. J NUTR BIOCHEM. 2006 Sep; 17 (9): 571-88.
(18) Figueroa A. Impact of L-Citrulline Supplementation and Whole-Body Vibration Training On Arterial Stiffness and Leg Muscle Function in Obese Postmenopausal Women with High Blood Pressure. EXD GERONTOL. 2015 Mar; 63: 35-40.
(19) Kuhn E. [The Effect of Work Load on Amino Acid Metabolism]. Vnitr Lek. 1994 Jul; 40 (7): 411-5.
(20) Brodan V. Changes of Free Amino Acids in Plasma of Healthy Subjects Induced by Physical Exercise. EUR J Application Physiol Occupance Physiol. 1976 Mar 9; 35 (1): 69-77.
(21) SURÉDA A. Blood Cell No Synthesis in Response to Exercise. Nitric Oxide. 2006 Aug; 15 (1): 5-12.
(22) Wijnands Kap. Arginine and Citrullline and the Immune Response in SEPSIS. Nutrients 2015, 7 (3), 1426-1463.
(23) Loiking YC. Reduced Citrulline Production in SEPSIS is related to decrease novo arginine and nitric oxide production. Am. J. Clin. NUTR. 2009, 89, 142–152.
(24) Wijnands Ka. Citrulline a more follow -up substrate Than Arginine to Restore No Production and the Microcirculation During Endotoxemia. PLOS ONE 2012, 7, E37439.F37
(25) Piton G. Plasma Citrulline Kinetics and Prognostics Value in Critically Ill patients. Intensive care med. 2010, 36, 702–706.
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(27) Asgeirsson T. Citrulline: a potential immunomodulator in sepsis. Surgery. 2011 Oct; 150 (4): 744-51.
(28) Cynober L. Citrulline: Just A Biomarker or A conditionally essential amino acid and a pharmaconutrient in Critically Ill patients? Criter. 2013 Mar 11; 17 (2): 122.
(29) Van Wijck K. L-Citrulline Improves Splanchnic Perfusion and Reduces Gut Injury During Exercise. Med SCI SPORTS EXERF. 2014 Nov; 46 (11): 2039-46.
(30) Balderas-Munoz K. Improvement of Ventricular Function in Systolic Heart Failure Patients with Oral L-Citrulline Supplementation. CARDIOL J. 2012; 19 (6): 612-7.
(31) Ochiai M. Short-Term Effects of L-Citrulline Supplementation On Arterial Stiffness in Middle-Agd Men. Int J Cardiol. 2012 Mar 8; 155 (2): 257-61.
(32) Figueroa A. Oral L-Citrulline Littenate Supplement Blood Pressure Response to Cold Pressor Test in Young Men. AM J Hypertens. 2010 Jan; 23 (1): 12-6.
(33) Sanchez-Gonzalez Ma. The Effects of Short Term L-Citrulline Supplementation On Wave Reflection Resorts To Cold Exposure With Competitor Isometric Exercise. AM J Hypertens. 2013 APR; 26 (4): 518-26.
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It is rare to know the names of the suppliers of the raw materials of the supplements that we consume. However, it is essential in order to ensure the traceability of the product.

The Base-Citrulline is a form of pure l-citrulline. At Nutrimuscle, we only use very high-end L-Citrulline whose quality is guaranteed by the Japanese leader in pharmaceutical biotechnology, Biokyowa Inc. Biokyowa included HACCP and ISO9001 is specialized in the production of pure amino acids For over 30 years. Indeed, what matters primarily to us is the quality of raw materials, your health and the results you will get using our nutritional supplements. This quality is essential for amino acids such as the Nutrimuscle Base Citrulline that you often consume (every day or even several times a day) and in large quantities.

Citrulline is generally marketed in 2 forms: L-Citrulline which is the purest form, and the Malatis de Citrulline which actually combines 2 amino acids: the L-Citrullin + of the DL-Malate.
So, when you use 1 gram of citrulline malate supplement, there are not really 1 gram of l-citrulline in it, because part of the supplement is made up of this second amino acid.
The respective proportions of each These amino acids can vary depending on the manufacturers (30 to 40 % DL-Malatia). It is therefore difficult to guess its contribution in Citrulline if the ratio is not specified (which is often the case).

the pure l-citrulline, that used for the nutrimuscle base-citrulline, is Composed of 100 % citrulline, which thus makes it possible to take higher doses of L-Citrulline in order to accompany muscle anabolism. On the contrary, as the dl-malate of the Malatis de Citrulline does not have an anabolic function, it represents a bad investment for its budget supplements.

no chemical or genetic manipulation
Unlike many lesrullines " Low cost "which is made from human hair, the Nutrimuscle L-Citrulline does not contain any animal or human substance. The Nutrimuscle L-Citrulline is produced thanks to a patented fermentation process from vegetable sugar. Thanks to exclusive purification techniques, the purity of the Nutrimuscle Base-Bases reaches 99.5 %, which is above the average pharmaceutical standard required by 98 %. The remaining 0.5 % are other amino acids.

If many cheap lesrullines come from China, this is not the case with the Nutrimuscle L-Citrulline. Our L-Citrulline is manufactured in an ultra-modern pharmaceutical factory certified HACCP and ISO9001 in the United States. The Nutrimuscle L-Citrulline is not developed from GMOs. It is manufactured without involving GMO substance. The Nutrimuscle L-Citrulline does not contain allergens such as gluten, soy, peanut, seafood, etc.

With leucine, citrulline is the second anabolic amino acid for muscle cells (8-9-10-11). But what should be noted with Citrulline is that, unlike leucine, the level of which is directly modulated by our protein ingestion, the citrulline intake remains very low, even if we eat a lot of protein , because almost no food contains citrulline.

only direct supplementation in the basis of the basis or indirect in glutamine or arginine can increase the levels of citrulline in the body. The disadvantage of indirect supplementation by glutamine or arginine is that we are dependent on the pace of conversion of these citrulline precursors. However, we have no taking on the conversion speed. This limiting factor does not arise with direct supplementation in L-Citrulline Base.

The taking of Citrulline increases arginine levels identically to the direct L-Arginine socket (12-13). Indeed, a part of arginine supplementation is degraded during digestion, which is not the case with Citrulline (14). The latter benefits from an almost perfect absorption.
Following an oral intake, the urinary losses of Citrulline are minimal, which proves that the absorption and retention capacities of the body are excellent, even in high doses (15 ). Thus, 3 to 6 g of citrulline make it possible to double the level of arginine in the blood (16).

This property of Citrulline gives it the status of indirect, but very effective Booster of the production of NO (nitrogen monoxide). NO is a gas, produced by the blood vessels which facilitate circulation in the muscles which increases their oxygenation and their congestion. These two properties of Citrulline explain that it is used as well as booster before training and as a sexual booster, in particular, in synergy with arginine.

In heart patients, 3 g oral intake of citrulline per day is quite effective in improving blood circulation (30). In healthy seniors, the daily oral taking of 5.6 g of Citrulline makes it possible to "rejuvenate" their cardiovascular system (31).

In young men in good health, 6 g of citrulline allows the cardiovascular system to better face stress induced by the cold (32). As Citrulline promotes blood circulation during an effort, it will play a cardioprotection role during a sporting event (33).
Citrulline is an important amino acid for the maintenance of human immune activity (22).

Unfortunately, in case of infection, when we need Citrulline most, the level of this amino acid collapses (23-24). During an infection, a low level of Citrulline is associated with a higher mortality rate (25-26). Indeed, the body needs citrulline to increase the manufacture of nitrogen monoxide (many immune cells use to destroy pathogens). A lack of NO reduces anti-infectious defenses. It is possible to overthrow the situation by supplementing yourself in the Nutrimuscle L-Citrulline (27).

Our sexual capacities are closely linked to the production of NO. Citrulline is therefore quite capable of overcoming deficiencies or even boosting sexual endurance in men who do not suffer from an erection problem. For example, in men suffering from erection problems, the daily intake of 1.5 g of Citrulline allows 50 % of users to find a normal erection (compared to 8 % in those using a placebo) (37).

At rest, blood irrigation of the digestive system is very important. During an effort, the blood migrates from the digestive system to the moving muscles, therefore irrigation and oxygenation of the digestive system can be reduced by 80 % or more. This blood rarefaction results in an oxygen shortage at the entire digestive system.

After the effort, the return of oxygen to a normal level can induce significant damage to the intestinal mucosa. Free radicals are massively formed locally, which can destroy many digestive cells. Intestinal permeability increases, which promotes attacks by pathogenic agents as well as bad digestion.

research shows that taking 10 g of citrulline before intense physical effort multiplies by 40 the level of citrulline in blood (29). These results only reflect the fact that our body produces very little citrulline. The level of arginine in the blood is multiplied by two. Thanks to Citrulline, the blood irrigation allowed by the vasodilator action of the overproduction of no remains three times higher than with a placebo, during the effort. All this without abandoning the muscles since it is the whole blood circulation of the body which is favored. In addition, Citrulline has antioxidant properties which makes it possible to fight against the influx of free radicals (1). Thus, the aggression of the digestive system induced by the sporting effort is greatly attenuated.

To sportsmen for its anabolic action on muscles;
to sedentary for its multiple health benefits of the organism or as a sexual booster.